Endocrine Abstracts

Objective: It is well-established that hyperthyroidism of Graves disease is caused by generation of TSH-receptor stimulating autoantibodies. However, in some patients TRAB titers may be in normal levels. The rate and the burden of TRAB negative disease vary between studies. In this study, we compared the clinical and laboratory parameters of 170 patients (85 TRAB positive and 85 TRAB negative) that were diagnosed to have Graves disease in our department....

Background: Thiol/disulfide homeostasis plays an important role in antioxidative defense mechanism, detoxification, signal transport, management of enzyme activity and trascription factors, and apoptosis. When thiol/disulphide homeostasis breaks down, these important cellular functions get deranged. Pathologies secondary to oxidative stress are seen in organeles in which this homeostasis is deranged. The aim of the study was to investigate dynamic thiol/disulfide homeostasis i...